5 Best Weed Killers for Lawn Reviews

4.9 (98.69%) 61 vote[s]

41% Glyphosate Formula
Size: 1-Gallon
Rainproof in 2 Hours
Grass Killer Plus
Unique Formula
Size: 1.33 GAL
Rainproof in 10 minutes
RM43 Weed Killer
43% Glyphosate Formula
Size: 1-Gallon
Weed Prevention for 1 Year
Roundup Control
Unique Formula
Size: 32-Ounce
Rainproof in 30 minutes
Amine Weed Killer
Item Weight: 2.5 pounds
Size: 1 Quart
Controls broadleaf weeds

1. Compare-N-Save Concentrate Grass and Weed Killer – Best Long-Term Value

Compare-N-Save Concentrate

Compare-N-Save is a well known brand for weed killer. Their concentrate grass and weed product works extremely well to kill off weed problems at the root system, but it does take longer than a Roundup solution.

The issue is that the concentrated version seeks out the root system, rather than just killing the plant on the surface. You can still see results in a few days.

With a year’s supply, you can quickly take care of all the weeds trying to ruin your lawn. However, you should be careful to use it in a spot sprayer, as it will kill everything that it touches, including your grass.

2. Roundup 5725070 Extended Control Grass Killer – Best Overall Weed Killer

Roundup Extended Control

Roundup has always been the standard for weed killer. This version includes a pump to make it easy to spot spray and kill weeds in their tracks. The solution is rain proof within 10 minutes and shows results that very same day.

Roundup also provides a weed-killing guarantee, so if you do have issues with the quality, you can return it.

While the weed killer works well, the sprayer is a little difficult to control and makes it harder to get a spot spray the first few times. You’ll have to pump the sprayer to load up the solution and then spray it directly on the spot where you want to kill the weed. If you spray any of the areas around the weed, you will also kill the grass.

You can see that it starts working right away, but it may take 2 to 3 days to see the weed fully disappear. Customers reported that you can also spray areas that are weed-prone to get rid of future weeds as well.

3. RM43 Glyphosate Plus Weed Preventer – Most Potent Weed Killer

Glyphosate Plus

You have to be extremely careful with this next weed killer. As tested, the RM43 is one of the fastest working weed killers on the market. However, the extreme potency of its formula can destroy your lawn if you don’t practice spraying beforehand.

You want to make sure that you only use this on your toughest weed spots, as it may cause problems for your lawn if you spray too much.

This is truly a professional-grade quality weed killer. While it may not work right away, you should see results the same day, and after a few weeks, you shouldn’t see any more weeds growing in the same areas that you sprayed.

This solution does kill everything you spray, including shrubs, brush, vines, weeds, and other pesky plants that you don’t want to see popping up around your manicured lawns. If you have a larger area, you can use this solution with a hose attachment to kill any annoying vegetation growing on your property. We liked how quickly this weed killer worked and that weeds didn’t come back even after 60 days.

4. Roundup Extended Control Weed and Grass Killer – Great Weed Killer & Prevention Formula


Roundup consistently makes great weed-killing products that are convenient to use. Unlike the other formula, this bottle doesn’t have a nozzle. You will need to use the concentrated solution with your own sprayer or hose. This is a new formula that is meant to kill existing weeds while also killing off new plants before they can grow for up to four months.

This formula works well to kill weeds at the root. You can spray this weed killer around a number of areas that are weed-prone, such as sidewalks, driveways, fences, foundation, curbs, and retaining walls to prevent any weeds for months. It starts working within a few hours, and you can see results the very same day.

As far as long-term prevention, Roundup’s concentrated formula has a potency that kills off plants quickly, preventing new weed growth right in the same exact spot that you sprayed. If you are looking for an accurate killer, this is the spot formula to use. So far, there have been no new, pesky weeds after 60 days. Customers report that this weed killer does prevent weeds from coming back even after four months as well.

5. Southern AG 2 Amine Weed Killer – Best Value Weed Killer

Amine Weed Killer

The 2,4-D Amine Weed Killer from Southern Ag is a wonderful concentrated formula that gets the job done. For the price, you really can’t beat the amount of formula you get. You can use about 1 to 4 pints per acre, depending on the number of plant pests cluttering your lawn.

This is best used to control broadleaf types of weeds, goathead stickers, clove plants, and other pesky weeds around wooded areas.

One thing we did notice is that it takes awhile to see results. It takes about 10 to 14 days to kill the weeds, but after that, you won’t see any more weeds for over 60 days. If you have a lot of acreage, this weed killer works extremely well to load up in a sprayer for bulk weed-killing action. Customers reported that this weed killer works extremely well for prevention and doesn’t cost as much as many other weed killers on the market.

Buyer’s Guide – Weed Killers

There are two ways that weed killers can get rid of weeds that are ruining your lawn:

  • Contact Weed Killers: These are concentrated formulas that kill any plant on the spot. These show results within hours, so it almost instantly kills the weed. Although these work pretty fast, they typically destroy the plant above the soil but aren’t able to kill the roots. However, these are extremely potent and results-based formulas to use with weeds that spread through seeds. You can kill off these seeds by spraying down the area. This means that weeds like crab grass, types of nettle, plant mallow, and types of bindweed are annihilated by most contact products.
  • Systemic Weed Killers: These formulas work because they can be spread into the root system and destroy the plant at the base. This means that weeds won’t grow and come back after a few days or weeks. They will likely be permanently gone, or at least gone for multiple months. These work the best for perennial types of weed plants, and they work extremely well for pesky weeds that won’t go away with other killer formulas.

Other Features to Look for in Weed Killers

  • Kills weeds fast
  • Rainproof in 1 to 2 hours
  • Visible results in one week
  • Prevents weeds from returning for 4 months
  • Large size for extended long-term use


If you are looking for a strong weed killer, then Roundup is likely the best formula to use, especially if you want to see the weeds gone quickly. However, long-term prevention is better with the extended control formula.


Hello, my name is Jane Smith and I’m an author of this blog. Using weed killer seems inevitable, especially when highly recommended organic options fail to get rid of weeds.

One Comment

  1. RoundUp will always be my favorite weed killer. I’ve been using the product for a decent amount of years and it continues to work wonders every single time. Never have I had any complaints and I highly recommend getting yourself some if you deal with weeds often.

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